Neuroblastoma (NB), a devastating pediatric cancer originating from neural crest cells crucial for nervous system development, poses a significant therapeutic challenge.Despite chemotherapy being the primary treatment, approximately 70% of high-risk NB cases develop resistance.Autophagy is vital for neuronal development, balance, and differentiatio
The proteins S100A9 and S100A12 are associated with the human S100 calcium-binding protein family.These proteins promote interaction with target windbreaker proteins and alter their conformation when they bind to calcium ions in EF-hand motifs.The V domain of RAGE (Receptor for Advanced Glycation End products) is crucial for S100A9 binding.The bind
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP.SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors.A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropic virus, but not other viruses.Although previous stu